Back to results
US 2023/0220401 A1Published application
Human alzheimer's disease and traumatic brain injury associated tau variants as biomarkers and methods of use thereof
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsMichael SIERKS, Lalitha VENKATARAMAN, Wei XIN
Life of this patent
Estimating the term…
Abstract
The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.
Claims15
1-31. (canceled)
A binding molecule,
- wherein the binding molecule preferentially binds to human traumatic brain injury (TBI)-associated tau and comprises an amino acid sequence at least 95% identical to:
- (a) an antibody heavy chain variable domain and light chain variable domain of SEQ ID NO:42, or
- (b) a designed ankyrin repeat protein (DARPin) of SEQ ID NO:44, SEQ ID NO:48, SEQ ID NO:52, or SEQ ID NO:54;
- wherein differences from the heavy chain variable domain and light chain variable domain of (a) or the DARPIN of (b) are conservative substitutions.
1 more element
Dependencies are inferred from the claim text.