Induced pluripotent cell comprising a controllable transgene for conditional immortalisation
AssigneeReneuron Limited
InventorsSteve PELLS, Marcela ROSAS, Randolph CORTELING
Life of this patent
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Abstract
The invention relates to induced pluripotent stem cells that are generated from cells, for example Adult Stem Cells, that are conditionally-immortalisable. In particular, the invention relates to induced pluripotent stem cells generated from stem cell lines comprising a controllable transgene for conditional immortalisation, and the progeny of those induced pluripotent stem cells such as cells of the haematopoietic lineage. Induced pluripotent stem cells, haematopoietic progeny cells derived from those pluripotent cells, compositions comprising those cells, methods of making all of those cells, and uses of all of those cells are also described.
Claims29
A cell of a haematopoietic lineage, that is derived from an induced pluripotent stem cell comprising a controllable transgene for conditional immortalisation.
(canceled)
A method of producing a cell of haematopoietic lineage from a pluripotent stem cell, comprising the steps of (i) reprogramming a conditionally-immortalised stem cell to form a pluripotent cell;
- and (ii) differentiating the pluripotent cell into a cell of a haematopoietic lineage.
(canceled)
Dependencies are inferred from the claim text.