Bicyclic compounds and use thereof

A compound of formula (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug, chelate, non-covalent complex, or solvate thereof,

• wherein,
• represents a single bond or a double bond;
• L is a bond, —O—, —NH—, —(CRdRc)n—, —S—, —S(═O)—, —S(═O)2—, —C═C—, —C≡C— or C3-C5 cycloalkyl,
• X1 and X2 are each independently selected from C or N;
• X3 is CRf or NRf;
• X4 is CRj or NRj;
• and at least one of X1, X2, X3 or X4 is N;
• R1 is selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 alkoxyl, C6-C10 aryl, 5-18 membered heteroaryl, C3-C10 cycloalkyl, or 3-10 membered heterocyclyl;
• wherein the 5-18 membered heteroaryl and 3-10 membered heterocyclyl optionally comprising 1, 2 or 3 hetero atoms independently selected from N, O or S;
• the C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 alkoxyl, C6-C10 aryl, 5-18 membered heteroaryl, C3-C10 cycloalkyl and 3-10 membered heterocyclyl are each optionally substituted with one or more halogen, —OH, —CN, oxo, amino, C1-C6 alkyl, C1-C6 alkoxyl, C2-C6 alkenyl, C3-C5 cycloalkyl, C2-C6 alkynyl, C1-C6 haloalkyl, —C1-C6 alkylene-ORc, —C0-C6 alkylene-C═ORc, —NO2, —ORc, —SRc, —NRaRb, —C(═O)Rc, —C(═O)ORc, —C(═O)NRaRb, —NC(═O)Rc, —S(═O)Rc, —S(═O)2Rc, —S(═O)2NRaRb, —S(═O)(═NRa)Rb, —P(═O)NRaRb and/or —P(═S)NRaRb;
• R2 is selected from H, deuterium, halogen, —CN, —OH, ═N—OH, C1-C5 haloalkyl, amino, C1-C10 alkoxyl, —O—C(═O)—C1-3 alkyl, —C(═O)—O—C1alkyl or —NRaRb;
• R3 is selected from H, deuterium, halogen, —CN, —OH, —N—OH, C1-C10 alkyl, C2-C10 alkenyl, C1-C5 haloalkyl, C1-C10 alkoxyl, —O—C(═O)—C1-C3 alkyl, —C(═O)—O—C1-C3 alkyl or C2-C10 alkynyl, the C1-C10 alkyl, C2-C10 alkenyl, C1-C5 haloalkyl, C1-C10 alkoxyl, —O—C(═O )—C1-C3 alkyl, —C(═O)—O—C1-C3 alkyl are each optionally substituted with one or more H, halogen, —CN, —OH, amino, C1-C5 alkyl, C2-C6 alkenyl and/or C1-C5 haloalkyl;
• or R2 and R3 together form an oxo group;
• R4 and R5 are each independently selected from H, halogen, —OH, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C5 cycloalkyl or 3-6 membered heterocyclyl, the C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C5 cycloalkyl and 3-6 membered heterocyclyl are each optionally substituted with one or more halogen, —CN, —OH, amino, C1-C5 alkyl, C2-C6 alkenyl and/or C1-C5 haloalkyl;
• or R4 and R5 together with the C atom to which they are attached form a substituted or unsubstituted cyclopropyl;
• R6 is selected from H, —CN, halogen, —OH, —NO2, —NH2, oxo, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C5 cycloalkyl or 3-6 membered heterocyclyl;
• the C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C5 cycloalkyl and 3-6 membered heterocyclyl are each optionally substituted with one or more H, halogen, —CN, —OH, amino, oxo, C1-C5 alkyl, C2-C6 alkenyl and/or C1-C5 haloalkyl;
• or two R6 together with the C atom to which they are attached form a substituted. or unsubstituted C3-C5 cycloalkyl or 3-5 membered heterocyclyl;
• or R6 and R5 together with the C atom to which they are attached form a substituted or unsubstituted C3-C4 cycloalkyl;
• Rd and Re are each independently selected from H, halogen, CN, —NRaRb, C1-C10 alkyl and C3-C10 cycloalkyl;
• or Rd and Re together form an oxo group;
• Rf is selected from absent, H, —CN, halogen, C1-C10 alkyl, C1-C10 haloalkyl, C3-C10 cycloalkyl, oxo, or —NRaRb;
• the C1-C10 alkyl, C1-C10 haloalkyl and C3-C10 cycloalkyl are each optionally substituted with one or more H, halogen, —CN, —OH, amino, C1-C5 allyl, C2-C6 alkenyl and/or C3-C5 haloalkyl;
• Rj is selected from H, —NO2, —CN, halogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, haloalkyl, cycloalkyl, C3-C10 cycloalkyl, 3-10 membered heterocyclyl, C6-C10 aryl, 5-10 membered heteroaryl, —C1-C6 alkylene-ORc, —ORc, —SRc, —NRaRb, —C(═O)Rc, —C(═O)ORc, —C(═O)NRaRb, —NC(═O)Rc, —S(═O)Rc, —S(═O)2Rc, —S(═O)2NRaRb, —S(═O)(═NRa)Rb, P(═O)RaRb, or P(═S)RaRb;
• wherein the 5-10 membered heteroaryl and 3-10 membered heterocyclyl optionally comprising 1, 2 or 3 heteroatoms independently selected from N, O or S;
• the C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C3-C10 cycloalkyl, 3-10 membered heterocyclyl, C6-C10 aryl and 5-10 membered heteroaryl are each optionally substituted with one or more halogen, hydroxyl, amino, P(═O)Me2, P(═S)Me2, —S(═O)2—C1-C3 alkyl, —S(═O)2—C3-C5 cycloalkyl, —S(═O)—C1-C3 alkyl, —S(═O)—C3-C5 cycloalkyl, CN, C1-C6 alkyl, C1-C6 alkoxyl and/or C1-C6 haloalkyl;
• Ra, Rb and Rc are each independently selected from H, C1-C10 alkyl, C1-C10 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, 3-10 membered heterocyclyl, C6-C10 aryl or 5-10 membered heteroaryl;
• n is 1, 2 or 3;
• m is 0, 1, 2, 3 or 4.