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US 2023/0219014 A1Published application
Contained production of pharmaceutically pure crystals
AssigneeBiosyn Arzneimittel GmbH
InventorsOrtwin Kottwitz, Thomas Stiefel
Life of this patent
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Abstract
The present invention relates to means and methods for producing crystals or crystalline substances in a contained vessel. In particular, crystals or crystalline substances, which are useful as pharmaceutical ingredients, can be manufactured.
Claims15
A method for manufacturing a crystalline substance, wherein the method employs vacuum crystallization of a solution of the substance to be crystallized, comprising the following steps:
- (i) applying vacuum to a vessel containing a solution of the substance to be crystallized to start crystallization, and
- (ii) drying an obtained crystal cake in the vessel, wherein during drying a condenser trap connected to the vessel is used for removing solvent from the crystal cake, wherein solvent from the crystal cake is frozen in the condenser trap and thereby removed from the crystal cake.
A device for manufacturing a crystalline substance comprising
- (i) a reactor which can be heated and/or cooled from outside, which is connected via connection line to
- (ii) a condenser trap, and is connected via connection line to
- (iii) a vacuum unit suitable for regulating the pressure conditions in the reactor and the condenser trap.
Dependencies are inferred from the claim text.