Aminocarbonylcarbamate compounds
AssigneeSK Biopharmaceuticals Co., Ltd.
InventorsYoung-Soon KANG, Jin-Yong CHUNG, Cheol-Young MAENG, Han-Ju YI, Ki-Ho LEE, Joon HEO, Eun-Hee CHAE, Yu-Jin SHIN
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Abstract
The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.
Claims15
-15. (canceled)
A method for treating a dopamine reuptake-related disease comprising:
- administering to a mammal in need thereof an oral or parenteral formulation comprising
- (a) a therapeutically effective amount of a compound of Formula (I), or a compound selected from the group consisting of:
- 2-amino-3-(2-chlorophenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-(2,4-dichlorophenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-(3,4-dichlorophenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-(4-chlorophenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-(3-chlorophenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-(4-nitrophenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-(4-tert-butylphenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-(2-fluorophenyl)propyl (aminocarbonyl)carbamate;
- (2R)-2-amino-3-(2-chlorophenyl)propyl (aminocarbonyl)carbamate;
- (2R)-2-amino-3-(2,4-dichlorophenyl)propyl (aminocarbonyl)carbamate;
- (2R)-2-amino-3-(3,4-dichlorophenyl)propyl (aminocarbonyl)carbamate;
- 2-amino-3-phenylpropyl(aminocarbonyl)carbamate;
- and
- (2R)-2-amino-3-phenylpropyl(aminocarbonyl)carbamate;
- or pharmaceutically acceptable salt thereof and
- (b) a therapeutically effective amount of an agent selected from the group consisting of amphetamine, methylphenidate, dextroamphetamine, dexmethylphenidate, lisdexamfetamine, and a pharmaceutically acceptable salt thereof,
- wherein
- X is independently halo, alkyl, alkoxy or nitro;
- m is 0, 1, 2, 3 or 4
- n is 1 or 2;
- R1 and R2 are independently H— or alkyl;
- R3 is H—, alkyl or aralkyl;
- and
- R4 is H— or aryl,
- wherein at least one of R1, R2, R3 and R4 is not H—.
A compound or hydrochloride salt thereof, wherein the compound is selected from the group consisting of:
- (2R)-2-amino-3-phenylpropyl (aminocarbonyl)methylcarbamate;
- (2R)-2-(dimethylamino)-3-phenylpropyl (aminocarbonyl)methylcarbamate;
- (2R)-2-amino-3-phenylpropyl (aminocarbonyl)benzylcarbamate;
- (2R)-2-amino-3-phenylpropyl (aminocarbonyl)ethylcarbamate;
- (2R)-2-amino-3-(2-chlorophenyl)propyl (aminocarbonyl)methylcarbamate;
- (2R)-2-amino-3-(4-chlorophenyl)propyl (aminocarbonyl)methylcarbamate;
- (2R)-2-amino-3-(2,4-dichlorophenyl)propyl (aminocarbonyl)methylcarbamate;
- (2R)-2-amino-3-(3,4-dichlorophenyl)propyl (aminocarbonyl)methylcarbamate;
- (2S)-2-amino-3-phenylpropyl (aminocarbonyl)methylcarbamate;
- (2R)-2-amino-3-(4-nitrophenyl)propyl (aminocarbonyl)methylcarbamate;
- (2R)-2-amino-3-(4-methylphenyl)propyl (aminocarbonyl)methylcarbamate;
- (2R)-2-amino-3-(4-ethoxyphenyl)propyl (aminocarbonyl)methylcarbamate;
- and
- (2R)-2-amino-4-phenylbutyl (aminocarbonyl)methylcarbamate.
Dependencies are inferred from the claim text.