Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis
AssigneeIcahn School of Medicine at Mount Sinai
InventorsWillem Mulder, Jordi Ochando, Zahi Fayad, Mounia Braza, Raphaël Duivenvoorden, Francois Fay
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Abstract
Methods and compositions for inducing long-term tolerance by hybrid nanoparticles are provided. Compositions and formulations comprising hybrid nanoparticles with inherent affinity for innate immune cells are provided.
Claims23
1-59. (canceled)
A method for reducing tissue rejection in a patient in need thereof, the method comprising administering to the patient an effective amount of a composition comprising a high-density lipoprotein (HDL)-derived nanoparticle which comprises a mTOR inhibitor selected from rapamycin or an ester or prodrug thereof, a phospholipid, and a apolipoprotein A-I (apoA-I).
Dependencies are inferred from the claim text.