Heterologous combination prime:boost therapy and methods of treatment
AssigneeChildren's Hospital of Eastern Ontario Research Institute Inc.
InventorDavid F. STOJDL
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Abstract
The present disclosure provides a Farmington virus formulated to induce an immune response in a mammal against a tumour associated antigen. The Farmington virus may express an antigenic protein that includes an epitope from the tumour associated antigen. The Farmington virus may be formulated in a composition where the virus is separate from an antigenic protein that includes an epitope from the tumour associated antigen. The present disclosure also provides a prime:boost therapy for use in inducing an immune response in a mammal. The boost includes a Farmington virus, or a composition that includes a Farmington virus.
Claims53
A Farmington virus comprising a nucleic acid that is capable of expressing a tumour associated antigen or an epitope thereof.
A composition comprising a Farmington virus comprising a nucleic acid that is capable of expressing a tumour associated antigen or an epitope thereof, the composition being formulated to induce an immune response in a mammal against the tumour associated antigen.
A composition comprising a Farmington virus and an antigenic protein that includes an epitope from a tumour associated antigen, wherein the Farmington virus is separate from the antigenic protein, the composition being formulated to induce an immune response in a mammal against the tumour associated antigen.
A heterologous combination prime:boost therapy for use in inducing an immune response in a mammal, wherein the prime is formulated to generate an immunity in the mammal to a tumour associated antigen, and the boost comprises:
- a Farmington virus comprising a nucleic acid that is capable of expressing a tumour associated antigen or an epitope thereof and is formulated to induce the immune response in the mammal against the tumour associated antigen.
A method of enhancing an immune response in a mammal having a cancer, the method comprising a step of:
- administering to the mammal a composition comprising a Farmington virus comprising a nucleic acid that is capable of expressing a tumour associated antigen or an epitope thereof,
- wherein the mammal has been administered a prime that is directed to the tumour associated antigen or an epitope thereof;
- and
- wherein the prime is immunologically distinct from the Farmington virus.
Dependencies are inferred from the claim text.