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US 2023/0210964 A1Published application
Compositions and methods for detoxifying bacterial endotoxins and hydrogen sulfide by recombinant fusion enzymes
OwnerSundaram Ramasamyinventor
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Abstract
Compositions comprising an engineered or non-naturally occurring polypeptides comprising two or more domains selected from Sulfide quinone oxidoreductase, Thiosulfate Sulfurtransferase and persulfide dioxygenase, and a phosphate binding motif are provided along with methods of detoxifying bacterial endotoxins and H2S with such compositions.
Claims30
A composition comprising an engineered or non-naturally occurring polypeptide comprising two or more domains selected from:
- sulfide quinone oxidoreductase (SQOR), Thiosulfate sulfurtransferase (TST) or sulfurtransferase domain engineered to comprise a phosphate binding motif, and persulfide dioxygenase (PDO.
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Dependencies are inferred from the claim text.