Loading patent…
AssigneeAZTherapies, Inc.
InventorsLevi B. Watkin, Philip G. Ashton-Rickardt
Estimating the term…
The invention provides compositions and methods for suppressing autoimmune components of neurodegenerative diseases and thereby providing therapeutic effects to patients suffering from such diseases, Compositions and methods include immunosuppressive moieties such as regulatory T cells (Tregs) and proteins expressed by Tregs coupled to a chimeric antigen receptor or protein that specifically binds one or more glial cell markers. Therapeutically effective doses of said compounds for treating neurodegenerative diseases including progressive supranuclear palsy (PSP), Parkinson's disease (PD), Alzheimer's, Huntington's disease, amyotrophic lateral sclerosis (ALS), chronic traumatic encephalopathy (CTE), multiple sclerosis, and prion diseases are disclosed.
An engineered protein comprising a glial cell-specific binding protein coupled to a molecule expressed by a regulatory T cell (Treg).
An engineered protein comprising a glial cell-specific binding protein coupled to a molecule that mimics the activity of a molecule expressed by a regulatory T cell (Treg).
A method for measuring the ability of a CAR molecule expressing a scFv specific for a protein to bind to a Treg cell that expresses said protein, wherein the scFv and the protein are labeled with different fluorescent labels and a shear force is applied for an incubation period.
Dependencies are inferred from the claim text.