Carbon nanotubes and complexes thereof for treating and detecting ocular tumors
AssigneeThe Regents of the University of Michigan
InventorsHakan Demirci, Nicholas Kotov, Yichun Wang
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Abstract
Disclosed herein are compositions and methods for injecting compounds into a vitreous body. Carbon nanotubes can be functionalized with a variety of agents, such as therapeutic agents and/or diagnostic agents, which can be injected into a vitreous body for treatment or detection of ocular tumors such as retinoblastoma. The carbon nanotubes can effectively penetrate the ocular tumor, making them effective carriers for the therapeutic and/or diagnostic agents.
Claims35
A method of treating an ocular tumor in a subject in need thereof, comprising:
- injecting a composition into a vitreous body of the subject, wherein the composition comprises a complex of a carbon nanotube and a therapeutic agent.
A method of detecting an ocular tumor in a subject, the method comprising:
- injecting a composition into a vitreous body of the subject, wherein the composition comprises a complex of a carbon nanotube and a diagnostic agent;
- and
- detecting a signal from the diagnostic agent.
An injectable composition for intravitreal injection into a vitreous body of an eye, comprising:
- a complex of a carbon nanotube and a therapeutic or diagnostic agent;
- and
- a pharmaceutically acceptable excipient.
Use of a carbon nanotube for administration of a therapeutic or diagnostic agent into a vitreous body.
Dependencies are inferred from the claim text.