Method for producing blockpoymers by means of linking blocks by a transpeptidase, and block polymers obtained by transpeptidase linking

A block polymer having at least a first block 1 and a second block 2 comprising the following structure:

• block 1- peptide intermediate sequence 1—block 2 wherein the peptide intermediate sequence 1 bridging block 1 and block 2 contains a sequence or is a sequence selected from the following group:
• -(I/L)(P/A)XT(G)1-5-(SEQ ID NOs:
• 18-22), -(I/L)(P/A)XT(A)1-5-(SEQ ID NOs:23-27), -NP(Q/K)T(G)1-5-(SEQ ID NOs:
• 28-32), -NP(Q/K)T(A)1-5-(SEQ ID NOs:33-37), -QVPT(G)1-5-(SEQ ID NOs:
• 38-42), -QVPT(A)1-5-(SEQ ID NOs:
• 43-47), -LAXT(G)1-5-(SEQ ID NOs:
• 48-52), -LAXT(A)1-5-(SEQ ID NOs:
• 56-60), -LPXS(G)1-5-(SEQ ID NOs:
• 61-65), -LPXS(A)1-5-(SEQ ID NOs:
• 66-70),
• -N(X)1-5-(SEQ ID NOs:71-73), -D(X)1-5-(SEQ ID NOs:
• 74-76), -LPNT(G)1-5-(SEQ ID NOs:
• 77-81), -LPNT(A)1-5-(SEQ ID NOs:82-87), IPKT(G)1-5 (SEQ ID NO:
• 95), IPKT(A)1-5 (SEQ ID NO:96), APKT(G)1-5 (SEQ ID NO:
• 97), APKT(A)1-5 (SEQ ID NO:
• 98), DPKT(G)1-5 (SEQ ID NO:
• 99), DPKT(A)1-5 (SEQ ID NO:
• 100), SPKT(G)1-5 (SEQ ID NO:
• 101), SPKT(A)1-5 (SEQ ID NO:

, APAT(G)1-5 (SEQ ID NO:

• 103), APAT(A)1-5 (SEQ ID NO:
• 104) and LPEC(G) 1-5 (SEQ ID NO:
• 105), LPEC(A)1-5 (SEQ ID NO:
• 106), (M/L/V) (P/T/A/S)A(A/L/T/S/V/I)(G)1-5 (SEQ ID NO:
• 107) and (M/L/V) (P/T/A/S)A(A/L/T/S/V/I)(A)1-5 (SEQ ID NO:
• 108), wherein X is any possible amino acid,
• and wherein block 1 and block 2 are independently selected from:
• nanoparticles, non-peptide polymers, and recombinant proteins.

, APAT(G)1-5 (SEQ ID NO:

• 103), APAT(A)1-5 (SEQ ID NO:
• 104) and LPEC(G)1-5 (SEQ ID NO:
• 105), LPEC(A)1-5 (SEQ ID NO:
• 106), M/LN)(P/T/A/S)A(A/L/T/SN/1)(G)1-5 (SEQ ID NO:
• 107) and -(M/LN)(P/T/A/S)A(A/L/T/S/V/1)(A)1-5 (SEQ ID NO:
• 108), and wherein block 1, block 2 and block 3 are independently selected from:
• nanoparticles, non-peptide polymers, and recombinant proteins.