Solvent removing apparatus and method of manufacturing microsphere using the same
AssigneeInventage Lab Inc.
InventorsSanghun Lee, Chan Hee Chon, Ju Hee Kim
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Abstract
A solvent removing apparatus includes a container containing an emulsion comprising a first raw material of a continuous phase and a second raw material of a dispersed phase, an impeller rotating in the container to stir the emulsion, and a foam breaker spaced apart from the impeller on an upper portion of the impeller, positioned below a surface of the emulsion to be submerged in the emulsion when the emulsion is calm, and rotating to reduce foam generated during stirring of the emulsion.
Claims15
An apparatus for removing solvent, the apparatus comprising:
- a container containing an emulsion comprising a first raw material of a continuous phase and a second raw material of a dispersed phase;
- an impeller configured to rotate in the container to stir the emulsion;
- and
- a foam breaker spaced apart from the impeller on an upper portion of the impeller, the foam breaker positioned below a surface of the emulsion to be submerged in the emulsion when the emulsion is calm, the foam breaker configured for rotating to reduce foam generated during stirring of the emulsion.
A method of manufacturing microsphere, the method comprising:
- preparing a first raw material and preparing a second raw material comprising a biodegradable polymer, drug and solvent;
- forming an emulsion including the first raw material in a continuous phase and the second raw material in a dispersed phase using the first raw material and the second raw material;
- providing the emulsion to an apparatus for removing solvent;
- and
- extracting and removing the solvent of the dispersed phase of the emulsion by rotating an impeller and a foam breaker of the apparatus;
- wherein the apparatus comprises:
- a container for accommodating the emulsion;
- the impeller configured for rotating in the container to stir the emulsion;
- and
- the foam breaker spaced apart from the upper portion of the impeller, the foam breaker positioned below a surface of the emulsion to be submerged in the emulsion when the emulsion is calm, the foam breaker configured for rotating to reduce foam generated during stirring of the emulsion.
Dependencies are inferred from the claim text.