Animal model for oxidative stress research and use thereof
AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsYoung-Ki PAIK, Hae Lim JEONG, Jun Young PARK, Soo Han BAE, Jeong Su PARK
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Abstract
The present invention relates to an animal model for oxidative stress research and use thereof, and more specifically, the present invention can utilize a mutant of RCAT having a regulatory function for an antioxidant stress regulator in Caenorhabditis elegans and a human cell line expressing RCAT as animal and human cell line models for oxidative stress research, using the mutant and the human cell line.
Claims8
An animal model for oxidative stress research, comprising a regulator of cat (RCAT) gene deletion mutant represented by SEQ ID NO:
- 1.
An antioxidant composition comprising a regulator of cat (RCAT) gene represented by a base sequence of SEQ ID NO:
- 2 or 3, or a protein encoded therefrom.
A method for screening an antioxidant drug, the method comprising:
- handling of an animal model for oxidative stress research, including a regulator of cat (RCAT) gene deletion mutant represented by a base sequence of SEQ ID NO:
- 1 with an antioxidant candidate drug;
- and
- measuring whether a generation amount of reactive oxygen species (ROS) is reduced in the animal model.
Dependencies are inferred from the claim text.