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US 2023/0183786 A1Published application
Methods for identifying and modulating co-occurant cellular phenotypes
AssigneeMassachusetts Institute of Technology
InventorsAlexander K. Shalek, Alexander S. Genshaft, Carly G.K. Ziegler, Jeffrey F. Van Humbeck
Life of this patent
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Abstract
The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
Claims6
-12. (canceled)
A cell functionalizing barcoded tag comprising:
- (a) a polyadorned molecule, wherein the molecule comprises 2 to 5 substituents comprising;
- (i) a click-enabled moiety, wherein the click-enabled moiety comprises an azide, tetrazine, tetrazole, or nitrone;
- and,
- (ii) an oligonucleotide barcode comprising a spatial barcode.
1 more element
-34. (canceled)
Dependencies are inferred from the claim text.