Process for the preparation of 1-bromo-2,4,5-trifluorobenzene
AssigneeAarti Industries Limited
InventorsMirik GOGRI, Prashant POTNIS, Surender DHINGRA
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Abstract
A process for the preparation of 1-bromo-2,4,5-trifluorobenzene from 2,4,5-trifluoroaniline or sulfate salt thereof. A process for the preparation of 1 ,2,4-trifluorobenzene from 2,4,5-trifluoroaniline and then converting into 1-bromo-2,4,5-trifluorobenzene.
Claims20
A process for the preparation of 1-bromo-2,4,5-trifluorobenzene comprising the steps of:
- a) converting 2,4,5-trifluoroaniline or a sulfate salt thereof into an intermediate, wherein the intermediate is formed by reacting 2,4,5-trifluoroaniline or a sulfate salt thereof with nitrosulphuric acid or the intermediate is formed by reacting 2,4,5-trifluoroaniline with sodium nitrite in the presence of a mineral acid and a peracid;
- and
- b) brominating the intermediate to obtain 1-bromo-2,4,5-trifluorobenzene
- .
A process for the preparation of 1-bromo-2,4,5-trifluorobenzene comprising the steps of:
- a) diazotizing 2,4,5-trifluoroaniline or a sulfate salt thereof using nitrosulphuric acid to obtain 2,4,5-trifluorophenyl diazonium salt;
- and
- b) brominating the 2,4,5-trifluorophenyl diazonium salt using a brominating agent in the presence of a metal bromide or in-situ generated metal bromide to obtain crude 1-bromo-2,4,5-trifluorobenzene,
- .
A process for the preparation of 1-bromo-2,4,5-trifluorobenzene comprising the steps of:
- a) deaminating 2,4,5-trifluoroaniline in the presence of sodium nitrite, mineral acid and a peracid to obtain 1,2,4-trifluorobenzene;
- and
- b) brominating 1,2,4-trifluorobenzene to obtain 1-bromo-2,4,5-trifluorobenzene,
- .
A process for the preparation of an intermediate to prepare 1-bromo-2,4,5-trifluorobenzene comprising:
- converting 2,4,5-trifluoroaniline or sulfate salt thereof into an intermediate, wherein the intermediate is formed by reacting 2,4,5-trifluoroaniline or a sulfate salt thereof with nitrosulphuric acid to form 2,4,5-trifluorophenyl diazonium salt or by reacting 2,4,5-trifluoroaniline with sodium nitrite in the presence of a mineral acid and a peracid to form 1,2,4-trifluorobenzene.
Dependencies are inferred from the claim text.