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US 2023/0174475 A1Published application
Disulfiram derivatives as aldh1a1 and magl inhibitors
AssigneeBatterjee Medical College
InventorZiad OMRAN
Life of this patent
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Abstract
A disulfiram derivative of formula (I) wherein R1 and R2 are independently —CH2CH2COOH, —CH2CH2COOEt, optionally substituted methylenepyridyl, optionally substituted methylenefuranyl, or optionally substituted methylenethiopenyl, may be useful in aldehyde dehydrogenase 1a1 (ALDH1a1) and/or monoacylglycerol lipase (MAGL)-mediated diseases or disorders. Such derivatives may avoid or limit aldehyde dehydrogenase 2 (ALDH2) and/or fatty acid amide hydrolase (FAAH) antagonism.
Claims20
A disulfiram derivative of formula (I),
- optionally as a salt, solvate, tautomer, stereoisomer, or mixture thereof,
- wherein R1 and R2 are independently —CH2CH2COOH, —CH2CH2COOEt, methylenepyridyl, methylenethiophenyl, or methylenefuranyl.
Dependencies are inferred from the claim text.