Method for preparing chiral 4-aryl-ß-amino acid derivative

A method for preparing a chiral 4-aryl-β-amino acid derivative, the chiral 4-aryl-β-amino acid derivative is a β-amino acid derivative having a structure as shown in Formula I,

• wherein R-configuration or S-configuration is marked with * in the stereocenter;
• the preparation method comprises hydrogenating an enamine compound having a structure as shown in Formula III in an organic solvent in the presence of a catalyst containing a transition metal and BIBOPs;
• wherein Ar is a phenyl, substituted with 1-5 substituents or a mixture of 1-5 substituents independently selected from halogen, trifluoromethyl, alkoxy;
• PG is hydrogen, aldehyde group, acetyl, benzyl, Boc, Cbz, PMB, Fmoc, COOR1, CONR2;
• Z is OR1, SR and NR3R4;
• wherein
• R1═H, C1-6 alkyl;
• R2═H, C1-6 alkyl or three-membered to six-membered heterocycle containing nitrogen, oxygen and sulfur,
• R3 and R4 are each independently H, C1-6 alkyl, C4-10 cycloalkyl, aryl, or R3 and R4 bonded to a nitrogen atom to be formed a C4-7 membered heterocycle having additional heteroatom optionally independently selected from O, S, N—C1-5 alkyl.