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US 2023/0173056 A1Published application
Persistent memory t-cell responses to cancer and infectious-disease antigens by manipulation of amino acid-catabolism pathways
AssigneeThe Regents of the University of California
InventorDennis Hartigan-O'Connor
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Abstract
Provided herein are recombinant polynucleotides including a first nucleic acid sequence encoding an antigen, and a second nucleic acid sequence encoding an enzyme of an amino acid catabolic pathway. The provided recombinant polynucleotides are particularly useful for inducing long-lived immune responses having improved memory characteristics. Also provided are pharmaceutical compositions, viral particles, and host cells including the disclosed recombinant polynucleotides, and methods for using the disclosed materials.
Claims53
A recombinant polynucleotide comprising:
- a first nucleic acid sequence encoding an antigen;
- and
- a second nucleic acid sequence encoding an enzyme of an amino acid catabolic pathway.
Dependencies are inferred from the claim text.