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US 2023/0168256 A1Published application
Methods for using protein biomarkers in idiopathic pulmonary fibrosis
AssigneeBoard of Regents, The University of Texas System
InventorsNagarjun Konduru Venkata, Sitaramaraju Adduri
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Abstract
The present disclosure includes exosomal protein biomarkers for differential diagnosis of idiopathic pulmonary fibrosis including a five-protein signature determined using mass spectrometry-based proteiomic analysis of plasma extracellular vesicles (EVs) for differential diagnosis of idiopathic pulmonary fibrosis.
Claims29
A method of preparing a human subject sample containing EVs and exosomes comprising:
- extracting a human subject sample;
- producing a sample from said human subject sample, wherein the human subject sample contains EVs and a subpopulation enriched in exosomes;
- and
- performing proteomic analysis of plasma extracellular vesicles (EVs) in the sample containing EVs and the subpopulation enriched in exosomes.
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A method for diagnosing idiopathic pulmonary fibrosis (IPF) using exosomal protein biomarkers, comprising:
- extracting a human subject sample containing EVs and a subpopulation enriched in exosomes;
- performing proteomic analysis of plasma extracellular vesicles (EVs) in the human subject sample containing EVs and the subpopulation enriched in exosomes;
- identifying a protein signature for at least two exosomal protein biomarkers for IPF;
- and
- using the protein signature to determine if the at least two exosomal protein biomarkers for IPF are elevated compared to a predetermined baseline level.
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Dependencies are inferred from the claim text.