Adhesive article and method of making same

A method of making an adhesive article, comprising:

• applying an active pharmaceutical ingredient to a first area of a substrate;
• applying an adhesive to the substrate such that the adhesive overlaps the active pharmaceutical ingredient and is in contact with the substrate in a second area of the substrate;
• converting the substrate into a desired shape that includes all of the active pharmaceutical ingredient and at least a portion of the adhesive;
• and
• allowing the active pharmaceutical ingredient to diffuse into at least a portion of the adhesive.

An adhesive article comprising:

• an active pharmaceutical ingredient;
• a substrate comprising a first surface and a second surface, wherein the second surface comprises a first area and a second area;
• a first adhesive layer disposed on the first area of the second surface of the substrate, the first adhesive layer comprising a first surface in contact with the second surface of the substrate and a second surface opposed to the second surface of the substrate, wherein the active pharmaceutical ingredient is present in the first adhesive layer at a first concentration;
• and
• a second adhesive layer comprising a first surface and a second surface opposed to the first surface, wherein a first portion of the first surface of the second adhesive layer is in contact with the second surface of the first adhesive layer and a second portion of the first surface of the second adhesive layer is disposed on the second area of the second surface of the substrate, wherein the active pharmaceutical ingredient in the second portion of the second adhesive layer is present at a second concentration;
• wherein the second concentration is less than the first concentration.