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US 2023/0160904 A1Published application
Reagent for mass spectrometry
AssigneeRoche Diagnostics Operations, Inc.
InventorsRobert Hahn, Dieter Heindl, Hans-Peter Josel, Uwe Kobold, Hannes Kuchelmeister, Simon Loibl, Heribert Maerz, Giuseppe Prencipe, Martin Rempt
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Abstract
The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.
Claims17
A compound for quantitative detection of an analyte using mass spectrometric determination,
- wherein said compound comprises a permanent charge, wherein said compound is capable of covalently binding to the analyte,
- wherein said compound has a mass m1 and a net charge z1,
- wherein the compound is capable of forming at least one daughter ion having a mass m2<m1 and a net charge z2<z1 after fragmentation by mass spectrometric determination,
- wherein m1/z1<m2/z2.
1 more element
A complex for quantitative detection of an analyte using mass spectrometric determination,
- wherein the complex is formed by the analyte and a compound, which are covalently linked to each other, wherein the complex comprises a permanent charge,
- wherein said complex has a mass m3 and a net charge z3,
- wherein the complex is capable of forming at least one daughter ion having a mass m4<m3 and a net charge z4<z3 after fragmentation by mass spectrometric determination,
- wherein m3/z3<m4/z4.
1 more element
(canceled)
Dependencies are inferred from the claim text.