Method of producing a bioactive surface
AssigneeStichting Radboud universitair medisch centrum
InventorsDion VOERMAN, Roelof HAMMINK, Martijn VERDOES, Carl Gustav FIGDOR
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Abstract
The present invention is directed to nanofilaments for polymer brushes, to polymer brushes comprising the nanofilaments and methods of making the same. In particular, the invention provides water soluble nanofilaments which may be grafted to a surface and which may be functionalised with (bio)molecules.
Claims36
A nanofilament for forming a polymer brush, wherein the nanofilament comprises first and second portions;
- wherein the first portion comprises a plurality of functional repeat units each having a first functional group and optionally a plurality of non-functional repeat units;
- wherein the second portion comprises a plurality of functional repeat units each having a second functional group and optionally a plurality of non-functional repeat units;
- and
- wherein the first and second functional groups are different.
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A method of producing a nanofilament for a polymer brush, the method comprising either:
- (a)
- (i) providing a first polymerisable composition comprising an amount of a first monomer having a first functional group and an amount of a catalyst and optionally an amount of a second non-functional monomer;
- (ii) polymerizing the first monomer, and if present the non-functional monomer, to provide a first polymer composition;
- (iii) adding an amount of a second monomer having a second functional group, and optionally an amount of a non-functional monomer, to the first polymer composition to provide a second polymerisable composition;
- and
- (iv) polymerizing the second monomer, and if present the non-functional monomer, to produce the nanofilament;
- or
- (b)
- (i) providing a first polymerisable composition comprising an amount of a second monomer having a second functional group and an amount of a catalyst and optionally an amount of a non-functional monomer;
- (ii) polymerizing the first monomer, and if present the non-functional monomer, to provide a first polymer composition;
- (iii) adding an amount of a first monomer having a first functional group, and optionally an amount of a non-functional monomer, to the first polymer composition to provide a second polymerisable composition;
- and
- (iv) polymerizing the first monomer, and if present non-functional monomer, to produce the nanofilament;
- wherein the first and second functional groups are different.
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Dependencies are inferred from the claim text.