Detection of Molecule-Nanoparticle Interactions with Ligand Shells
AssigneeUniversity of South Carolina
InventorsMorgan Stefik, Zachary Marsh
Life of this patent
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Abstract
A quartz crystal microbalance coated with functionalized nanoparticles used to detect molecule-nanoparticle interactions to assist with characterization of difficult to predict molecule-nanoparticle interactions for novel ligand chemistries and, particularly, mixed ligand nanoparticles exhibiting different ligand morphologies, in order to quantify nanoparticle-molecule interactions independently from more complex solvation requirements.
Claims16
A quartz crystal microbalance method for detecting molecular interactions with nanoparticles to quantify molecule-nanoparticle interactions comprising:
- preparing a nanoparticle film on a quartz crystal;
- exposing the nanoparticle film to at least one molecular vapor;
- and
- quantifying mass uptake via analyzing a resonant frequency of the quartz crystal.
A method to quantify mixed ligand shell molecule-nanoparticle interaction comprising:
- measuring vapor phase uptake of molecules into a solid nanoparticle film, deposited on a crystal, via nuclear magnetic resonance, wherein the nanoparticle film comprises mixed ligand nanoparticles with constant size and variable composition;
- and
- wherein the method is independent of solvation criteria.
Dependencies are inferred from the claim text.