Combinations of flavivirus proteins, peptide sequences, epitopes, and methods and uses thereof
AssigneeLa Jolla Institute for Immunology
InventorsSujan SHRESTA, Jason GREENBAUM
Life of this patent
Estimating the term…
Abstract
The present application relates to composition of matter, processes and use of composition of matter relating to flavivirus proteins, peptides, and epitopes, for example, for therapeutic or preventative vaccination against one or more flavivirus serotypes or species, and/or for inducing, enhancing, or sustaining an immune response against at least one flavivirus serotype or species. The flavivirus may be for example the Zika and/or Dengue virus.
Claims32
A composition comprising:
- a) a protein or peptide, or variant, homologue, derivative, or subsequence thereof, that comprises, consists, or consists essentially of a flavivirus B cell epitope, or a nucleic acid molecule encoding the protein or peptide, or variant, homologue, derivative, or subsequence thereof, and
- b) a protein or peptide, or variant, homologue, derivative, or subsequence thereof, that comprises, consists, or consists essentially of a flavivirus T cell epitope or a nucleic acid molecule encoding the protein or peptide, or variant, homologue, derivative, or subsequence thereof,
- wherein the composition elicits, stimulates, induces, promotes, increases, or enhances an antibody response and a T cell response against two or more different serotypes of a flavivirus or two or more different species of flavivirus.
-8. (canceled)
-14. (canceled)
-21. (canceled)
-27. (canceled)
-36. (canceled)
A composition comprising (a) at least one polypeptide having an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 11-14, (b) at least one polypeptide having an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 1-5, at least one polypeptide having an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 6-10, at least one polypeptide having an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 15-19, or at least one polypeptide having an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 20-24, and (c) a pharmaceutically acceptable buffer or excipient.
-48. (canceled)
(canceled)
-54. (canceled)
A composition comprising (a) at least one polynucleotide encoding an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 11-14, (b) at least one polynucleotide encoding an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 1-5, at least one polynucleotide encoding an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 6-10, at least one polynucleotide encoding an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 15-19, or at least one polynucleotide encoding an amino acid sequence at least 90% identical to a sequence set forth as SEQ ID NO:
- 20-24, and (c) a pharmaceutically acceptable buffer or excipient.
-66. (canceled)
(canceled)
-106. (canceled)
-117. (canceled)
Dependencies are inferred from the claim text.