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US 2023/0148084 A1Published application
Electrospinning of cartilage and meniscus matrix polymers
AssigneeScripps Health
InventorsDarryl D. D'LIMA, Shawn GROGAN, Clifford W. COLWELL, JR., Jihye BAEK
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Abstract
Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.
Claims23
1-100. (canceled)
A meniscal implant comprising a plurality of cross-linked polymer fibers, the polymer fibers of the plurality of cross-linked polymer fibers having a structure comprising:
- (a) a shell comprising a first polymer;
- and
- (b) a core comprising a second polymer,
- wherein the meniscal implant comprises a V-shape or a custom shape of a meniscus, and
- wherein the meniscal implant has a Young's modulus of about 100 MPa to about 300 MPa measured in a circumferential direction.
2 more elements
Dependencies are inferred from the claim text.