Macrocyclic compounds and uses thereof

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• A is C6-10 arylene, 5-12-membered heteroarylene, or 5-12-membered heterocycloalkylene;
• X1 is N or CRX;
• X2 is N or CRX;
• X3 is N or CRX;
• X4 is N or CRX;
• X6 is N or CRX′;
• X7 is N or CRX′;
• represents an optional double bond between X7 and X4 or X4 and X6, wherein one and only one double bond is present;
• X5 is a covalent bond, CH2, O, NR4, C(O)NR4, or NR4C(O);
• L1 is a covalent bond or C(R5)2, and L2 is C1-4 alkylene, or L1 and L2 combine to form a C3-6 cycloalkyl or a 4- to 6-membered heterocycloalkyl;
• R1 is halogen, C1-6 alkyl, C3-7 cycloalkyl, C6-10 aryl, 5- to 10-membered heteroaryl, 3- to 10-membered heterocycloalkyl, CN, NR6R7, NR6C(O)R7, NR6C(O)NH2, OR8, or C(O)NR6R7;
• R2 is absent, H, C1-6 alkyl, halogen, CN, or C1-6 alkoxy;
• each R3, when present, is independently OH, CN, halogen, C1-6 alkyl, or C1-6 alkoxy;
• n is 0, 1, or 2;
• each RX is independently H, ORX1, CN, halogen, or C1-6 alkyl, wherein RX1 is H or C1-6 alkyl;
• each RX′ is independently H, ORX1, CN, halogen, or C1-6 alkyl, wherein RX1 is H or C1-6 alkyl, or RX′ is absent if the carbon to which it is attached is part of a double bond;
• each R4 and R5 is independently H or C1-6 alkyl;
• each R6 and R7 is independently H, C1-6 alkyl, C3-7 cycloalkyl, or 3- to 10-membered heterocycloalkyl;
• or R6 and R7 together with the nitrogen atom to which they are attached form a 3- to 8-membered heterocycloalkyl ring;
• and
• R8 is independently H, C1-6 alkyl, or 4- to 6-membered heterocycloalkyl.