Polymer with cationic and hydrophobic side chains

A polymer comprising a hydrolysable polymer backbone, the polymer backbone comprising:

• (i) monomer units comprising a hydrophobic side chain;
• and
• (ii) monomer units comprising a cationic side chain comprising:
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NH2 or
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NHR2,
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NH—(CH2)s1—R4-R5;
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p1—NH—CH2—CHOH—R5;
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NH—(CH2)s1—R5;
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NH—CH(CONH2)—(CH2)s1—R5;
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NH—CH(CONH2)—(CH2)s1—R4-R5,
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NR2—(CH2)s1—R4-R5;
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NR2—CH2—CHOH—R5;
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NR2—(CH2)s1—R5;
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NR2—CH(CONH2)—(CH2)s1—R5;
• or
• —(CH2)p1—[NR2—(CH2)p2—]r1NR2—(CH2)p3—NR2—CH(CONH2)—(CH2)s1—R4- R5,
• wherein:
• each of p1 to p3 independently is an integer of 1 to 5;
• optionally wherein p1, p3, or both are greater than p2, and/or wherein p1, p3, or both are integers of 3 to 5;
• r1 is an integer of 0 to 5;
• s1 is an integer from 1 to 5;
• each instance of R2 is independently C1-C12 alkyl group, C2-C12 alkenyl group, C3-C12 cycloalkyl group, or C3-C12 cycloalkenyl group, or R2 is combined with a second R2 so as to form a heterocyclic group;
• each instance of R4 is independently —C(O)O—, —C(O)NH—, —C—O—C(O)—O—C—, —O—, or —S(O)(O)—;
• and
• R5 is a group comprising a polyalkylene oxide, a polyglycolic acid, a polylactic acid, or combination thereof;
• a tissue-specific or cell-specific targeting moiety;
• or a combination thereof.