Oleyl phosphocholine containing granulates
AssigneeOblita Therapeutics BVBA
InventorCaroline Jansen
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Abstract
The present invention relates to tablet dosage formulations of oleyl phosphocholine for oral administration and the processes for their preparation. Specifically, the present invention provides a process for preparing an oleyl phosphocholine containing granulate. The present invention further provides a process for preparing a pharmaceutical dosage formulation, such as a tablet or a capsule, comprising the oleyl phosphocholine containing granulate. The invention further provides any intermediate and/or en product resulting from these steps and processes.
Claims17
A process for making an olelyl phosphocholine (OlPC) containing granulate, said process comprises the consecutive steps of:
- a) preparing a mixture of olelyl phosphocholine, an anti-oxidant, a filler and, optionally, a granulation liquid and/or one or more further granulation excipients;
- b) processing the mixture prepared in step a) into a dry granulate;
- and
- c) milling the granulate produced in step b);
- characterized in that the antioxidant is vitamin E, vitamin E TPGS, apha-tocopherol acetate and/or alpha-tocopherol.
A process according to claim 4, wherein no solvent is added during any one of steps a), b) and c).
-17. (canceled)
Dependencies are inferred from the claim text.