Indoline compounds for inhibiting kif18a

A compound of Formula (II):

• or a pharmaceutically acceptable salt thereof, wherein:
• ring A is
• wherein Z1, Z2, Z3, and Z4 are each independently hydrogen or RD, wherein RD is halo, —OH, —NRa4C(O)ORa5, —NRa6Ra7, —N═S(O)Ra8Ra9, —ORa10, —S(O)Ra11, —S(O)(NRa12)Ra13, —S(O)2NRa14Ra15, —S(O)2Ra16, —(CRa17Ra18)0-1C(O)NRa19Ra20, —SRa21, —C(O)Ra22, —P(O)(Ra23)(Ra24), —C═NRa25, or C1-6 alkyl substituted with one or more substituents independently selected from the group consisting of —OH, cyano, C3-10 cycloalkyl, and 3- to 10-membered heterocycloalkyl optionally substituted with one or more halo or C1-3 alkyl,
• provided that
• (1) when Z4 is hydrogen, then at least one of Z1 and Z3 is RD;
• and
• (2) when Z4 is RD, then Z1 is RD, or
• wherein
• is a single bond or a double bond,
• Z5 is C—H, N, O, S, or N—X, wherein X is H or C1-6alkyl;
• Z6 is —NRa26C(O)NRa27Ra2, —NRa29C(O)ORa30, —N═S(O)Ra31Ra32, —S(O)Ra33, —S(O)(NRa34)Ra35, —S(O)2NRa36Ra37, —S(O)2Ra38, —SRa39, 3- to 10-membered heterocycloalkyl, —C(O)Ra40, or —CH(Z7)(Z8), wherein Z7 is hydrogen or —OH, and Z8 is C1-6 alkyl, C3-10 cycloalkyl optionally substituted with one or more halo, or 3- to 10-membered heterocycloalkyl optionally substituted with one or more halo, and
• ring C is 5- to 6-membered heteroaryl optionally substituted with one or more RE substituents, wherein each RE substituent is independently selected from the group consisting of halo, —OH, and C1-6 alkyl, or two RE substituents are taken, together with the atoms to which they are attached, to form C5-6 cycloalkyl, C5-6 cycloalkenyl, 5- to 6-membered heterocycloalkyl, 5- to 6-membered heterocycloalkenyl, or 5- to 6-membered heteroaryl;
• Ra4-Ra40 are each independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, 3- to 10-membered heterocycloalkyl, 3- to 10-membered heterocycloalkenyl, C6-14 aryl, or 5- to 12-membered heteroaryl, each optionally substituted with one or more substituents independently selected from the group consisting of halo, cyano, —OH, —O(C1-6 alkyl), C2-6 alkenyl, C3-10 cycloalkyl, —S(C1-6 alkyl), ═CR1a1R1a2, and C1-6 alkyl optionally substituted with one or more substituents independently selected from the group consisting of halo, —OH, and —O(C1-6 alkyl), wherein R1a1 and R1a2 are each independently hydrogen or C1-6 alkyl;
• ring B is C5-7 cycloalkyl, C5-7 cycloalkenyl, or 5- to 7-membered heterocycloalkyl wherein one or two of the ring atoms are each oxygen and the remaining ring atoms are each carbon;
• each RB group is independently halo or C1-6 alkyl optionally substituted with one or more halo;
• or two vicinal RB groups are taken together with the carbon atoms to which they are attached to form C3-10 cycloalkyl;
• or two geminal RB groups are taken together with the carbon atom to which they are attached to form C3-10 cycloalkyl;
• or two geminal RB groups are taken together to form a ═CR1a3R1a4 group, wherein R1a3 and R1a4 are each independently hydrogen or C1-6 alkyl;
• m is 0, 1, 2, 3, or 4;
• Y1 is N or CRC1;
• Y2 is N or CRC2;
• Y3 is N or CRC3;
• Y4 is N or CRC4;
• wherein no more than three of Y1, Y2, Y3, and Y4 are N;
• RC1-RC4 are each independently hydrogen or RF, wherein RF is halo, cyano, —OH, —NO2, —C(O)NRc1Rc2, —NRc3Rc4, —NRc5S(O)2Rc6, —P(O)Rc7Rc8, —N═S(O)Rc9Rc10, —S(O)(NRc11)Rc12, —S(O)2Rc13, —NRc14C(O)ORc15, —NRc16S(O)2(CH2)1-6NRc17C(O)Rc18, —O—S(O)2Rc19, or C1-6 alkyl substituted with one or more substituents independently selected from the group consisting of halo and —OH, and
• Rc1-Rc19 are each independently hydrogen, C3-10 cycloalkyl, or C1-6 alkyl optionally substituted with one or more substituents independently selected from the group consisting of halo, —O(C1-6 alkyl), —NHC(O)(C1-6 alkyl), and —OH;
• provided that
• (1) when ring B is unsubstituted cyclopentyl, then ring A is
• wherein at least one of Z1-Z4 is —S(O)2-(3- to 10-membered heterocycloalkyl) substituted with one or more halo,
• (2) when ring B is unsubstituted cyclohexyl and ring A is
• then at least one of RC1-RC4 is RF, and
• (3) when ring B is 5- to 7-membered heterocycloalkyl optionally substituted with 1-4 RB, then ring A is
• wherein at least one of Z1-Z4 is —S(O)2-(3- to 10-membered heterocycloalkyl) optionally substituted with one or more halo.