Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease

A compound of the Formula:

• or pharmaceutically acceptable salt thereof, wherein:
• R is —H or C1-C3 alkyl;
• is a group of the formula:
• R2 is a cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each optionally substituted with one to three R10 substituents, or R2 is a group of the formula:
• R3 is —H, halogen, —CN, C1-C6 alkyl C1-C6 haloalkyl, C3-C5 cycloalkyl, a heterocycle of 3 to 5 ring atoms containing 1, 2, or 3 ring heteroatoms independently selected from N, O, or S, or a heteroaryl of 5 ring atoms containing 1, 2, or 3 ring heteroatoms independently selected from N, O, or S;
• each of R4, R5 and R6 is independently —H, halogen, C1-C6 alkyl or C1-C6 haloalkyl;
• R7 is —CN, C1-C6 alkyl or C1-C6 haloalkyl;
• R8 is —H or C1-C6 alkyl;
• each R9 is independently —H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, or C3-C5 cycloalkyl;
• each R10 is independently —H, —CN, halogen, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, —SO2R11, —CONR11R11, —NR11R11, —NR11—CO2R11, —OH, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C3-C5 cycloalkyl, an optionally substituted heterocycle selected from pyrrolidine, pyrrolidinone, piperidine or morpholine, an optionally substituted phenyl, an optionally substituted 1,3-benzodioxole, an optionally substituted 2,3-dihydro-1,4-benzodioxine or an optionally substituted heteroaryl selected from pyrazole, isoxazole, isothiazole, imidazole, oxazole, or thiazole;
• wherein the optionally substituted C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl is each optionally substituted with a —CN, —OH, oxetanyl, or C1-C3 alkoxy;
• the optionally substituted C3-C5 cycloalkyl, phenyl, 1,3-benzodioxole, 2,3-dihydro-1,4-benzodioxine, heterocycle or heteroaryl is each optionally substituted with one to three substituents each independently selected from halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, —SO2R11, —NR11R11, —OH or —CN;
• and
• each R11 is independently —H or C1-C3 alkyl.