Pyridopyrimidinone derivatives and their use as aryl hydrocarbon receptor modulators

A compound of formula (I), or an enantiomer, diastereomer, racemate, solvate, hydrate, or pharmaceutically acceptable salt thereof:

• wherein:
• Ar1 and Ar2 are independently selected from a group consisting of halo, substituted or unsubstituted mono- or bicyclic C6-10 aryl, substituted or unsubstituted mono- or bicyclic C5-10 heteroaryl and substituted or unsubstituted mono- or bicyclic C3-10 heterocycloalkyl;
• L is absent(direct bond), H, halo, cyano, hydroxy, amino, nitro, ether(-O—), thioether(-S—), sulfinyl(-SO—), sulfonyl(-SO2—), sulfonylamido(-SO2NR2—), aminosulfonyl(—NR2SO2—), carbonyl(-(CO)—), amido(-(CO)NR2—), reverse amido(-NR2(CO)—), ester(-(CO)O—), substituted or unsubstituted C1-5 alkyl, substituted or unsubstituted mono- or bicyclic C3-10 cycloalkyl, substituted or unsubstituted mono- or bicyclic C4-10 heterocycloalkyl, substituted or unsubstituted mono- or bicyclic C6-10 aryl and substituted or unsubstituted mono- or bicyclic C5-10 heteroaryl;
• R1 is absent(direct bond), H, halo, cyano, hydroxy, amino, NHR3, OR3, phosphate, substituted or unsubstituted C1-3 alkyl phosphate, substituted or unsubstituted C1-5 alkyl, sulfinic acid(-SO—H), sulfonic acid(-SO2—H), sulfonylamide(-SO2NR22), aminosulfonic acid(—NR2SO2—H), carboxylic acid(-(CO)—H), carbonyl((-(CO)R2), amide(-(CO)NR22), reverse alkyl amide(-NH(CO)—R2), alkyl ester(-(CO)O—R2), sulfonate(-SO2—R2), C3-10 cycloalkyl, C1-5 alkylhydroxy, C1-5 alkenylhydroxy, C1-5 alkynylhydroxy, C1-5 alkylamine, C1-5 alkenylamine, C1-5 alkynylamine, substituted or unsubstituted mono- or bicyclic C3-10 heterocycloalkyl and substituted or unsubstituted mono- or bicyclic C5-10 heteroaryl;
• R2 is H, halo, hydroxy, amino, substituted or unsubstituted C1-5 alkyl, substituted or unsubstituted C1-5 alkoxy, substituted or unsubstituted C3-8 cycloalkyl and substituted or unsubstituted C1-5 alkyl carboxylic acid;
• R3 is H, substituted or unsubstituted C1-5 alkyl, C1-5 alkylacetyl(alkyl-CO—), C1-5 sulfonylalkyl(alkyl-SO2—), C1-5 sulfonylamidoalkyl(alkyl-SO2NR22), C1-5 amidoalkyl(alkyl-(CO)NR22), C1-5 reverse amidoalkyl(alkyl-NR2(CO)—), substituted or unsubstituted C1-5 alkoxy and substituted or unsubstituted C1-5 alkyl carboxylic acid.