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US 2023/0146956 A1Published application
Multimeric oligonucleotides with divided strands
AssigneeMpeg La, LLC
InventorJonathan Miles Brown
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Abstract
The present disclosure relates to multimeric oligonucleotides comprising subunits, each of the subunits independently comprises a single-stranded or double-stranded oligonucleotide. Each of the subunits is joined to another subunit by a covalent linker, and at least one subunit comprises at least one partial single-stranded oligonucleotide. The present disclosure also relates to methods of synthesizing the multimeric oligonucleotides and the methods of using the multimeric oligonucleotides disclosed herein.
Claims18
1-67. (canceled)
A multimeric oligonucleotide comprising subunits, wherein:
- each of the subunits independently comprises a single-stranded or double-stranded oligonucleotide;
- each of the subunits is joined to another subunit by a covalent linker;
- at least one subunit comprises at least one partial single-stranded oligonucleotide;
- wherein the multimeric oligonucleotide comprises:
- wherein:
- each is a single-stranded oligonucleotide;
- each is a partial single-stranded oligonucleotide;
- and
- each • is a covalent linker.
6 more elements
Dependencies are inferred from the claim text.