Heterocyclic compounds and their use for treatment of helminthic infections and diseases

A compound of Formula (I)

• or a pharmaceutically acceptable salt, tautomer, isotopologue, or stereoisomer thereof,
• wherein:
• W is N or NR;
• X is N, NR, O, or S;
• Y is N, NR, O, or S;
• R1 is 2-pyridyl, 3-pyridyl, pyrazinyl, or pyrimidyl, each unsubstituted or substituted with one or more substituents independently selected from halogen, CN, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C3-7 cycloalkyl, substituted or unsubstituted 3-6 membered heterocyclyl, —NR2, —COOR, —OR3, —SO2NR2, —SO2 (substituted or unsubstituted heterocyclyl), —N(R)CO(R4), —CON(R5)2, and substituted or unsubstituted C6-10 aryl;
• R2 is
• each unsubstituted or substituted with one or more substituents Z, wherein Z is independently selected from halogen, CN, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C3-7 cycloalkyl, substituted or unsubstituted 3-6 membered heterocyclyl, —NR(substituted or unsubstituted C3-7 cycloalkyl), —N(R)COR, —COOR, —SO2(C1-3 alkyl), —SO2NR2, —SO2 (substituted or unsubstituted heterocyclyl), —OR6, and —CON(R7)2;
• or two Z together with the carbons to which they are attached form a substituted or unsubstituted 5-6 membered heterocyclyl or substituted or unsubstituted C5-6 heteroaryl;
• Each R3 is independently selected from substituted or unsubstituted C1-5 alkyl, or substituted or unsubstituted 3-6 membered heterocyclyl;
• Each R4 is independently selected from substituted or unsubstituted C1-5 alkyl, or substituted or unsubstituted C3-6 cycloalkyl;
• Each R5 is independently selected from H, substituted or unsubstituted C1-5 alkyl, substituted or unsubstituted C3-6 cycloalkyl, and substituted or unsubstituted (C1-3 alkyl)(C3-6 cycloalkyl), or two R5 and the nitrogen to which they are attached form a substituted or unsubstituted 3 to 6 membered heterocyclyl;
• Each R6 is independently selected from substituted or unsubstituted C1-5 alkyl, substituted or unsubstituted C3-6 cycloalkyl, —(C1-3 alkyl)(substituted or unsubstituted C3-6 cycloalkyl), or substituted or unsubstituted 3-8 membered heterocyclyl;
• Each R7 is independently selected from H, and substituted or unsubstituted C1-5 alkyl, or two R7 and the nitrogen to which they are attached form a substituted or unsubstituted 3 to 6 membered heterocyclyl;
• RN is H, or substituted or unsubstituted C1-5 alkyl;
• and
• each R is independently selected from H and substituted or unsubstituted C1-4 alkyl;
• provided R1 and R2 are not both unsubstituted.