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US 2023/0146925 A1Published application
Depot formulations
AssigneeDurect Corporation
InventorsJeremy C. WRIGHT, Felix THEEUWES, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK
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Abstract
Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.
Claims20
A formulation comprising:
- (i) a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions;
- (ii) a linear polymer comprising lactide repeat units, wherein the linear polymer possesses a ratio R of lactide repeat units to total repeat units in the linear polymer;
- and
- (iii) one or more solvents that have a solvent capacity,
- wherein the linear polymer has a weight average molecular weight less than or equal to about 15,000 Daltons, and
- wherein
- (a) R satisfies the following:
- about 0.55≤R≤ about 0.95;
- (b) when R satisfies the following:
- about 0.55≤R≤0.85, the solvent capacity of the one or more solvents is greater than or equal to about 20%;
- and
- (c) when R satisfies the following:
- greater than about 0.85 to about 0.95, the solvent capacity of the one or more solvents is greater than or equal to about 10%.
10 more elements
A formulation comprising:
- (i) a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions;
- (ii) a linear polymer comprising lactide repeat units, wherein the linear polymer possesses a ratio R of lactide repeat units to total repeat units in the linear polymer;
- and
- (iii) one or more solvents that have a solvent capacity,
- wherein the linear polymer has a weight average molecular weight less than or equal to about 15,000 Daltons, and
- wherein:
- (a) R satisfies the following:
- about 0.55≤R≤0.85;
- and
- (b) the solvent capacity of the one or more solvents is greater than or equal to about 20%.
7 more elements
Dependencies are inferred from the claim text.