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US 2023/0146782 A1Published application
Deoxycholic acid compounds, pharmaceutical compositions and uses thereof
OwnerJessica Xinyun DUinventor
Life of this patent
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Abstract
Disclosed are a deoxycholic acid compound and a pharmaceutical composition thereof, and use thereof in the preparation of drugs for treating liver diseases. The structure of the deoxycholic acid compound is as shown by Formula I, or pharmaceutically acceptable salts thereof. The compounds have significantly liver-targeting characteristics, and the compounds reduce the drug concentration in the circulatory system while improving the efficacy, thereby reducing the toxic side effects.
Claims22
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 and R2 each are independently selected from the group consisting of:
- H, —COR′, —CONHR′, —CONR′R″, or —COOR′;
- R3 is selected from the group consisting of H, methyl, or ethyl;
- R4 is selected from the group consisting of:
- H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl, and heterocyclyl or substituted heterocyclyl;
- Linker is absent, or is selected from the group consisting of:
- alkylene or substituted alkylene, alkenylene or substituted alkenylene, alkynylene or substituted alkynylene, cycloalkylene or substituted cycloalkylene, arylene or substituted arylene, heteroarylene or substituted heteroarylene, and heterocyclylene or substituted heterocyclylene;
- R5 and R6 each are independently selected from the group consisting of:
- H, and alkyl or substituted alkyl;
- or R5 and R6 are linked to each other, and form a 3-7 membered ring with 0, 1, or 2 heteroatoms selected from the group consisting of O, S, or N, together with C atoms linked thereto;
- R is selected from the group consisting of:
- alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, aryl or substituted aryl, alkylene-aryl, alkylene-substituted aryl, heteroaryl or substituted heteroaryl, and heterocyclyl or substituted heterocyclyl;
- or
- R is selected from the group consisting of:
- inorganic cations selected from the group consisting of sodium ions, potassium ions, magnesium ions, or calcium ions;
- or organic cations selected from the group consisting of ammonium, tetramethylammonium, tetraethylammonium, tetrapropylammonium, or tetrabutylammonium;
- R′ and R″ each are independently selected from the group consisting of:
- H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl, and heterocyclyl or substituted heterocyclyl;
- and
- substituents of the substituted alkyl, the substituted alkylene, the substituted alkenyl, the substituted alkenylene, the substituted alkynyl, the substituted alkynylene, the substituted cycloalkyl, the substituted cycloalkylene, the substituted aryl, the substituted arylene, the alkylene-substituted aryl, the substituted heteroaryl, the substituted heteroarylene, the substituted heterocyclyl, or the substituted heterocyclylene each are independently selected from the group consisting of:
- halogen, cyano, amino, nitro, hydroxy, alkyl, alkoxyl, and modified alkyl.
19 more elements
A pharmaceutical composition, characterized in comprising a therapeutically effective amount of a compound of the following Formula I:
- or one or more of pharmaceutically acceptable salts thereof, and optionally a pharmaceutically acceptable carrier,
- in Formula I,
- R1 and R2 each are independently selected from the group consisting of:
- H, —COR′, —CONHR′, —CONR′R″, or —COOR′;
- R3 is selected from the group consisting of:
- H, methyl, or ethyl;
- R4 is selected from the group consisting of:
- H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl, and heterocyclyl or substituted heterocyclyl;
- Linker is absent, or is selected from the group consisting of:
- alkylene or substituted alkylene, alkenylene or substituted alkenylene, alkynylene or substituted alkynylene, cycloalkylene or substituted cycloalkylene, arylene or substituted arylene, heteroarylene or substituted heteroarylene, and heterocyclylene or substituted heterocyclylene;
- R5 and R6 each are independently selected from the group consisting of:
- H, and alkyl or substituted alkyl;
- or R5 and R6 are linked to each other, and form a 3-7 membered ring with 0, 1, or 2 heteroatoms selected from the group consisting of O, S, or N, together with C atoms linked thereto;
- R is selected from the group consisting of:
- alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, aryl or substituted aryl, alkylene-aryl, alkylene-substituted aryl, heteroaryl or substituted heteroaryl, and heterocyclyl or substituted heterocyclyl;
- or
- R is selected from the group consisting of:
- inorganic cations selected from the group consisting of sodium ions, potassium ions, magnesium ions, or calcium ions;
- or organic cations selected from the group consisting of ammonium, tetramethylammonium, tetraethylammonium, tetrapropylammonium, or tetrabutylammonium;
- R′ and R″ each are independently selected from the group consisting of:
- H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl, and heterocyclyl or substituted heterocyclyl;
- and
- substituents of the substituted alkyl, the substituted alkylene, the substituted alkenyl, the substituted alkenylene, the substituted alkynyl, the substituted alkynylene, the substituted cycloalkyl, the substituted cycloalkylene, the substituted aryl, the substituted arylene, the alkylene-substituted aryl, the substituted heteroaryl, the substituted heteroarylene, the substituted heterocyclyl, or the substituted heterocyclylene each are independently selected from the group consisting of:
- halogen, cyano, amino, nitro, hydroxy, alkyl, alkoxyl, and modified alkyl.
21 more elements
Dependencies are inferred from the claim text.