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AssigneeUnited Biomedical, Inc.
InventorsChang Yi Wang, Feng Lin, Shuang Ding
Estimating the term…
The present disclosure is directed to peptide immunogen constructs targeting portions of Pituitary adenylate cyclase-activating polypeptide (PACAP), compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions thereof. The disclosed peptide immunogen constructs have more than about 20 amino acids and contain (a) a B cell epitope having about more than about 9 contiguous amino acid residues from the PACAP receptor binding or activation regions of the full-length PACAP protein; (b) a heterologous Th epitope; and (c) an optional heterologous spacer. The disclosed PACAP peptide immunogen constructs stimulate the generation of highly specific antibodies directed PACAP for the prevention and/or treatment of migraine.
A PACAP peptide immunogen construct having about 20 or more amino acids, represented by the formulae:
An PACAP peptide immunogen construct comprising:
An isolated antibody or epitope-binding fragment thereof that specifically binds to the PAC1 binding or activation region of SEQ ID NOs:
Dependencies are inferred from the claim text.