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US 2023/0146515 A1Published application
Mitochondria-targeting peptides
AssigneeStealth BioTherapeutics Inc.
InventorsGuozhu Zheng, Mark J. Bamberger, Inese Smukste
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Abstract
Disclosed are non-natural peptides useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.
Claims30
A compound of Formula (I):
- wherein
- AA1 is selected from
- AA2 is selected from
- R1 is selected from
- R2a is selected from
- R2b is H or Me;
- R3 and R4 are independently selected from H and (C1-C6)alkyl;
- R5 and R6 are independently H, methyl, ethyl, propyl, cyclopropyl, or cyclobutyl;
- or R5 and R6 together with the N atom to which they are attached form a 4-6-membered heterocyclyl;
- R7 is selected from H, (C1-C6)alkyl, cycloalkyl, and aryl;
- R8 and R9 are independently selected from H, (C1-C6)alkyl, cycloalkyl, and aryl;
- or R8 and R9 together with the N atom to which they are attached form a 4-6-membered heterocyclyl;
- n is 1, 2, or 3;
- X is selected from
- and
- * denotes the point of attachment of X to R1.
13 more elements
-9. (canceled)
-13. (canceled)
-19. (canceled)
-23. (canceled)
-27. (canceled)
-30. (canceled)
(canceled)
(canceled)
-38. (canceled)
-43. (canceled)
-48. (canceled)
-54. (canceled)
Dependencies are inferred from the claim text.