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AssigneeJuventas Cell Therapy Ltd.
InventorsYun LIU, Lin SHI, Lulu LV, Pan XIE, Mengmeng CAO, Wang YANG, Jiaxing YANG, Fei WANG, Rui WANG
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Provided in the present disclosure is a method for using a four-plasmid system to prepare modified immune effector cells. The method comprises: forming a lentivirus by using four plasmids within 293T cells, extracting and obtaining the lentivirus, then transfecting immune effector cells by using the lentivirus, and expressing a chimeric antigen receptor. Also provided in the present disclosure is a use of the immune effector cell obtained by using the described method and of a composition containing the immune effector cell.
A plasmid combination, wherein the plasmid combination comprises plasmids Seq1, PMD2.G, pMDLg-pRRE and pRSV-Rev;
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A plasmid combination, wherein the plasmid combination comprises plasmids Seq1, PMD2.G, pMDLg-pRRE and pRSV-Rev;
Dependencies are inferred from the claim text.