SARS-CoV-2 SPIKE RECEPTOR BINDING DOMAIN AND COMPOSITIONS AND METHODS THEREOF
AssigneeRegents of the University of Minnesota
InventorsFrank Jonathan LEE, Yushun WAN, Jian SHANG
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Abstract
The present disclosure provides an isolated or purified SARS-CoV-2 Receptor Binding Domain (RBD) polypeptide and cells for producing such a polypeptide, as well as compositions and methods thereof.
Claims72
An isolated or purified polypeptide comprising a SARS-CoV-2 receptor binding domain (RBD) linked directly or through a linker group to a peptide tag (e.g., an affinity tag), wherein the SARS-CoV-2 RBD is between about 197 to about 237 amino acids in length.
An isolated or purified polypeptide comprising a SARS-CoV-2 receptor binding domain (RBD) linked directly or through a linker group to a peptide tag (e.g., an affinity tag),
- wherein the SARS-CoV-2 RBD is between about 197 to about 237 amino acids in length;
- and
- wherein the SARS-CoV-2 RBD comprises an amino acid sequence having at least about 90% identity to a sequence corresponding to SEQ ID NO:5, or wherein the SARS-CoV-2 RBD comprises an amino acid sequence having at least about 90% identity to a sequence corresponding to SEQ ID NO:2.
An isolated or purified polypeptide comprising a SARS-CoV-2 receptor binding domain (RBD) linked directly or through a linker group to a peptide tag (e.g., an affinity tag),
- wherein the SARS-CoV-2 RBD is between about 197 to about 237 amino acids in length;
- and
- wherein the SARS-CoV-2 RBD comprises an amino acid sequence having at least about 90% identity to a sequence corresponding to SEQ ID NO:10.
An isolated or purified polypeptide comprising a SARS-CoV-2 receptor binding domain (RBD) linked directly or through a linker group to a peptide tag (e.g., an affinity tag),
- wherein the SARS-CoV-2 RBD is between about 197 to about 237 amino acids in length;
- and
- wherein the SARS-CoV-2 RBD comprises an amino acid sequence having at least about 90% identity to a sequence corresponding to SEQ ID NO:2.
Dependencies are inferred from the claim text.