Method of Modulating the Number and the Distribution of Tumor-Infiltrating Leukocytes in Tumors
AssigneeNOXXON Pharma AG
InventorsAxel Vater, Dirk Zboralski
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Abstract
The present invention is related to a molecule capable of inhibiting signaling between SDF-1 and CXCR4 and/or CXCR7, wherein the molecule is for use in a method of modulating the number and/or the spatial distribution of tumor-infiltrating leukocytes in a tumor and/or metastases.
Claims25
-111. (canceled)
A method for establishing in the treatment and/or prevention of a tumor in a subject an SDF-1 gradient (a) in and/or around the tumor, (b) in and/or around metastases, (c) around the vasculature of the tumor and/or (d) around the vasculature of metastases, wherein the method comprises administering to the subject a molecule that inhibits signaling between SDF-1 and CXCR4 and/or CXCR7, wherein said molecule comprises an SDF-1 binding L-nucleic acid molecule.
Dependencies are inferred from the claim text.