Novel lysophosphatidic acid derivative

A compound represented by the following formula (I)

• wherein
• X is oxygen or sulfur,
• Y is oxygen, sulfur, NH, CH2, —-O—CH2—, or —CH2—O—,
• Q is a group represented by the following formula (A-1)
• wherein ring A is an aromatic heterocycle optionally further substituted by a substituent selected from the group consisting of
• halogen;
• optionally substituted alkyl;
• optionally substituted cycloalkyl;
• and
• optionally substituted alkoxy (wherein the aromatic heterocycle excludes indole and purine),
• or
• —C(═O)—,
• R1 is a group represented by the following formula (A-2)
• wherein ring B is cycloalkane or benzene, R7 in the number of n are each independently
• halogen,
• cyano,
• optionally substituted alkyl,
• optionally substituted cycloalkyl,
• optionally substituted alkoxy, or
• an optionally substituted aromatic hydrocarbon group, and n is an integer of 0-5,
• L1 is a single bond, NH, oxygen, sulfur, —R6—, —R6O—,—OR6≤, —R6NH—, —NHR6—, —R6S—, or —SR6—,
• R6 is an optionally substituted alkylene,
• (i) when Q is a group represented by the aforementioned formula (A-1),
• Z is CH2, oxygen, sulfur, or NR5, and
• R2, R3, R4, and R5 are each any of the following (i)-1 to (i)-4;
• (i)-1:
• R2 is hydrogen or optionally substituted alkyl,
• R3 and R4 are each independently hydrogen or optionally substituted alkyl, and
• R5 is hydrogen or optionally substituted alkyl, and the substituent of the optionally substituted alkyl is
• halogen;
• hydroxy;
• alkoxy;
• cycloalkyl optionally substituted by alkyl;
• amino optionally substituted by alkyl or acyl;
• phenyl optionally substituted 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl;
• or
• an aromatic heterocyclic group optionally substituted by 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl,
• or
• (i)-2:
• R2 is hydrogen or optionally substituted alkyl, and
• one of R3 and R4 is hydrogen or optionally substituted alkyl, and the other is bonded to R5 to form, together with a carbon atom bonded to R3 and R4 and a nitrogen atom bonded to R5, an optionally substituted cyclic amine,
• or
• (i)-3:
• 3 and R4 are each independently hydrogen or optionally substituted alkyl, and
• R2 is bonded to R5 to form, together with a carbon atom bonded to R2 and a nitrogen atom bonded to R5, an optionally substituted cyclic amine,
• or
• (i)-4:
• R5 is hydrogen or optionally substituted alkyl, and the substituent of the optionally substituted alkyl is
• halogen;
• hydroxy;
• alkoxy;
• cycloalkyl optionally substituted by alkyl;
• amino optionally substituted by alkyl or acyl;
• phenyl optionally substituted 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl;
• or
• an aromatic heterocyclic group optionally substituted by 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl, and
• one of R3 and R4 is hydrogen or optionally substituted alkyl, and the other is bonded to R2 to form, together with a carbon atom bonded to R3 and R4 and a carbon atom bonded to R2, an optionally substituted cycloalkane;
• or
• (ii) when Q is represented by —C(═O)—,
• Z is oxygen, sulfur, or NR5, and
• R2, R3, R4, and R5 are each any of the following (ii)-1 to (ii)-4;
• (ii)1:
• R2 is hydrogen or alkyl,
• R3 and R4 are each independently hydrogen or optionally substituted alkyl, and
• R5 is optionally substituted alkyl, and the sub stituent of the optionally substituted alkyl is
• halogen;
• hydroxy;
• alkoxy;
• cycloalkyl optionally substituted by alkyl;
• amino optionally substituted by alkyl or acyl;
• phenyl optionally substituted 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl;
• or
• an aromatic heterocyclic group optionally substituted by 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl,
• or
• (ii)-2:
• R2 is hydrogen, or alkyl, and
• one of R3 and R4 is hydrogen or optionally substituted alkyl, and the other is bonded to R5 to form, together with a carbon atom bonded to R3 and R4 and a nitrogen atom bonded to R5, an optionally substituted cyclic amine,
• or
• (ii)-3:
• R3 and R4 are each independently hydrogen or optionally substituted alkyl, and
• R2 is bonded to R5 to form, together with a carbon atom bonded to R2 and a nitrogen atom bonded to R5, an optionally substituted cyclic amine,
• or
• (ii)-4:
• R5 is optionally substituted alkyl, and the sub stituent of the optionally substituted alkyl is
• halogen;
• hydroxy;
• alkoxy;
• cycloalkyl optionally substituted by alkyl;
• amino optionally substituted by alkyl or acyl;
• phenyl optionally substituted 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl;
• or
• an aromatic heterocyclic group optionally substituted by 1 or 2 substituents selected independently from the group consisting of
• hydroxy,
• halogen,
• alkoxy,
• cycloalkyl optionally substituted by alkyl,
• amino optionally substituted by alkyl or acyl,
• alkyl optionally substituted by hydroxy or alkoxy, and
• alkylaminosulfonyl, and
• one of R3 and R4 is hydrogen or optionally substituted alkyl, and the other is bonded to R2 to form, together with a carbon atom bonded to R3 and R4 and a carbon atom bonded to R2, an optionally substituted cycloalkane,
• or a pharmacologically acceptable salt thereof.