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US 2023/0146071 A1Published application
Calibration fluid comprising pyrogallol for the calibration of blood gas, electrolyte, and/or metabolite instrument oxygen sensor(s)
AssigneeSiemens Healthcare Diagnostics Inc.
InventorsKevin Horan, Murli NARAYAN
Life of this patent
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Abstract
Compositions, devices, kits, and methods for calibrating at least one oxygen sensor in a blood gas, electrolyte, and/or metabolite instrument utilizing a calibration fluid comprising a pyrogallol oxygen scavenger.
Claims20
A method for monitoring the performance of a blood gas, electrolyte, and/or metabolite analyzer system, the method comprising the steps of:
- (i) inserting a sensor cartridge into a blood gas, electrolyte, and/or metabolite instrument, the sensor cartridge comprising:
- an amperometric sensor array comprising at least one sensor and at least one electrode, wherein the at least one sensor includes an amperometric pO2 sensor;
- at least one calibration and/or quality control reagent;
- and
- aqueous pyrogallol;
- (ii) activating the sensor cartridge to add aqueous pyrogallol to the at least one calibration and/or quality control reagent and incubating at a specific reaction temperature and for a specific reaction time sufficient to form at least one calibration fluid having a desired oxygen level;
- and
- (iii) contacting the at least one calibration fluid with the pO2 sensor for calibration and/or quality control of the blood gas, electrolyte, and/or metabolite instrument.
5 more elements
A method for monitoring the performance of a blood gas, electrolyte, and/or metabolite analyzer system, the method comprising the steps of:
- (i) inserting a sensor cartridge into a blood gas, electrolyte, and/or metabolite instrument, the sensor cartridge comprising:
- (a) an amperometric sensor array comprising at least one sensor and at least one electrode, wherein the at least one sensor includes an amperometric pO2 sensor;
- (b) a first calibration and/or quality control reagent;
- (c) a second calibration and/or quality control reagent having a pO2 value above zero mmHg;
- (d) aqueous pyrogallol;
- and
- wherein each of (b), (c), and (d) is separately disposed in a substantially air tight environment in the sensor cartridge until activation of the sensor cartridge;
- (ii) activating the sensor cartridge to add aqueous pyrogallol to the first calibration and/or quality control reagent and incubating at a specific reaction temperature and for a specific reaction time sufficient to form a first calibration fluid having a desired oxygen level;
- (iii) contacting the first calibration fluid with the pO2 sensor, whereby contact of the at least one pO2 sensor with the first calibration fluid sets a floor calibration measurement;
- and
- (iv) contacting the second calibration and/or quality control reagent with the pO2 sensor, whereby contact of the at least one pO2 sensor with the second calibration and/or quality control reagent sets a ceiling calibration measurement.
8 more elements
A method for monitoring the performance of a blood gas, electrolyte, and/or metabolite analyzer system, the method comprising the steps of:
- (i) inserting a sensor cartridge into a blood gas, electrolyte, and/or metabolite instrument, the sensor cartridge comprising:
- an amperometric sensor array comprising at least one sensor and at least one electrode, wherein the at least one sensor includes an amperometric pO2 sensor;
- a first calibration and/or quality control reagent;
- a second calibration and/or quality control reagent having a pO2 value above zero mmHg;
- a third calibration and/or quality control reagent having a pO2 value above zero mmHg;
- and
- aqueous pyrogallol;
- and
- (ii) activating the sensor cartridge to add aqueous pyrogallol to the first calibration and/or quality control reagent and incubating at a specific reaction temperature and for a specific reaction time sufficient to form a first calibration fluid having a pO2 value of about 0 mmHg;
- (iii) activating the sensor cartridge to add aqueous pyrogallol to the third calibration and/or quality control reagent and incubating at a specific reaction temperature and for a specific reaction time sufficient to form a third calibration fluid having a pO2 value between 0 mmHg and the pO2 value of the second calibration and/or quality control reagent;
- (iv) contacting the first calibration fluid with the pO2 sensor, whereby contact of the at least one pO2 sensor with the first calibration fluid sets a floor calibration measurement;
- (v) contacting the second calibration and/or quality control reagent with the pO2 sensor, whereby contact of the at least one pO2 sensor with the second calibration and/or quality control reagent sets a ceiling calibration measurement;
- and
- (vi) contacting the third calibration fluid with the pO2 sensor, whereby contact of the at least one pO2 sensor with the third calibration fluid sets a calibration measurement between the floor and ceiling measurements.
11 more elements
Dependencies are inferred from the claim text.