Burkholderia pseudomallei complex outer membrane vesicles as adjuvants
AssigneeThe Administrators of the Tulane Educational Fund
InventorsLisa Ann MORICI, James B. McLACHLAN, Christopher J.H. DAVITT, Jonathan R. KURTZ
Life of this patent
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Abstract
Outer membrane vesicles from bacteria of the Burkholderia pseudomallei complex can be used as adjuvants in compositions and methods to potentiate the immune response to immunogens.
Claims36
1-47. (canceled)
An immunogenic composition, said composition comprising (a) a plurality of outer membrane vesicles (OMVs) derived from one or more organisms of the B. pseudomallei complex (“Bpc”) and, (b) a non-Burkholderia immunogen from Clostridium botulinum, C. perfringens, Chlamydia psittaci, Coxiella burnetii, Ricinus communis, Rickettsia prowazekii, Vibrio cholerae, Cryptosportidium parvum, Yersinia pestis, Francisella tularensis, a Brucella species, E. coli O157:H7, Variola major virus, Machupol virus, Venezuelan equine encephalitis virus, eastern equine encephalitis virus, or western equine encephalitis virus (collectively, “the pathogenic organisms”).
The immunogenic composition of claim 53, wherein said Bpc species is B. pseudomallei.
A method of increasing a subject's immune response to a non-Burkholderia immunogen, said method comprising co-administering to said subject (a) a plurality of outer membrane vesicles (OMVs) derived from one or more organisms of the B. pseudomallei complex (“Bpc”) and, (b) a non-Burkholderia immunogen from Clostridium botulinum, C. perfringens, Chlamydia psittaci, Coxiella burnetii, Ricinus communis, Rickettsia prowazekii, Vibrio cholerae, Cryptosportidium parvum, Yersinia pestis, Francisella tularensis, a Brucella species, E. coli O157:H7, Variola major virus, Machupol virus, Venezuelan equine encephalitis virus, eastern equine encephalitis virus, or western equine encephalitis virus (collectively, “the pathogenic organisms”).
The method of claim, wherein said organisms of said Bpc are organisms of Burkholderia pseudomallei, B. mallei, B. oklahomensis, B. thailandensis, B. humptydooensis, Burkholderia spp. Clade A, Burkholderia spp. Clade B, or Burkholderia spp. Clade C, and have attenuated pathogenicity compared to wild type Burkholderia pseudomallei, B. mallei, B. oklahomensis, B. thailandensis, B. humptydooensis, Burkholderia spp. Clade A, Burkholderia spp. Clade B, or Burkholderia spp. Clade C, respectively.
Dependencies are inferred from the claim text.