Drug dosage determination devices and methods
AssigneeHoffmann-La Roche Inc.
InventorsGeraint Iwan DAVIES, David ELFANT, Martin JENKINS
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Abstract
The application relates to devices and methods for determining an administration regimen of a drug to a subject. Determining an administration regimen for a subject comprises computing the amount of drug to be administered to the subject per elemental period of time, and determining and evaluating combinations of at least two dosage forms that can be used to administered the amount of drug, against at least two different criteria. The methods of the invention find applications in the selection of administration regimen for drugs that are available in multiple dosage forms, and especially drugs that are administered routinely over prolonged periods, such as e.g. in the routine prophylaxis of haemophilia.
Claims20
A computing device comprising a processor and a memory, wherein the computing device is configured to determine an administration regimen of a drug to a subject by:
- receiving the value of at least one parameter associated with the subject;
- determining the amount of drug (At) to be administered to the subject per elemental period of time (t) based at least in part on the value of the at least one parameter associated with the subject, wherein the drug is available in at least two different dosage forms (D1, D2) that differ by the total amount of drug and/or the drug concentration in a dose of the dosage form;
- computing all minimal combinations (At [D1, D2, D1D2]) of the at least two different dosage forms that can be used to achieve the amount of drug (At) to be administered to the subject, wherein a minimal combination is a combination that reaches or exceeds the amount of drug (At) to be administered to the subject by using the minimum number of doses of each dosage form in a combination of dosage forms (D1, D2, D1D2);
- selecting a subset of the combinations (At [D1, D2, D1D2]) that satisfy at least a first criterion and a second criterion;
- and
- outputting the selected subset of combinations as the optimal administration regimen(s) for the subject.
A computer-implemented method for determining an administration regimen of a drug to a subject, the method comprising:
- receiving, at a processor, the value of at least one parameter associated with the subject;
- determining, by said processor, the amount of drug (At) to be administered to the subject per elemental period of time (t) based at least in part on the value of the at least one parameter associated with the subject, wherein the drug is available in at least two different dosage forms (D1,D2) that differ by the total amount of drug and/or the drug concentration in a dose;
- computing, by said processor, all minimal combinations (At [D1,D2, D1D2]) of the at least two different dosage forms that can be used to achieve the amount of drug (At), wherein a minimal combination is a combination that reaches or exceeds the amount of drug (At) to be administered to the subject by using the minimum number of doses of each dosage form in a combination of dosage forms (D1,D2, D1D2);
- selecting, by said processor, a subset of the combinations (At [D1,D2, D1D2]) that satisfy at least a first criterion and a second criterion;
- and
- outputting, by said processor, on a user interface, the selected subset of combinations as the optimal administration regimen(s) for the subject.
A method of treating a subject with a drug, the method comprising the steps of:
- determining, by a processor, an administration regimen of said drug to said subject, by:
- receiving, at the processor, the value of at least one parameter associated with the subject;
- determining, by said processor, the amount of drug (At) to be administered to the subject per elemental period of time (t) based at least in part on the value of the at least one parameter associated with the subject, wherein the drug is available in at least two different dosage forms (D1,D2) that differ by the total amount of drug and/or the drug concentration in a dose;
- computing, by said processor, all minimal combinations (At [D1,D2, D1D2]) of the at least two different dosage forms that can be used to achieve the amount of drug (At), wherein a minimal combination is a combination that reaches or exceeds the amount of drug (At) to be administered to the subject by using the minimum number of doses of each dosage form in a combination of dosage forms (D1,D2, D1D2);
- selecting, by said processor, a subset of the combinations (At [D1,D2, D1D2]) that satisfy at least a first criterion and a second criterion;
- and
- outputting, by said processor, the selected subset of combinations as the optimal administration regimen(s) for the subject;
- and
- administering said drug to said subject using one or said selected subset of combinations of said at least two different dosage forms.
Dependencies are inferred from the claim text.