Urea inhibitors of micro-rna

A compound of structural Formula I:

• or a salt or tautomer thereof, wherein:
• W1 is chosen from CR4 and N;
• W2 is chosen from CR5 and N;
• W3 is chosen from CR6 and N;
• Z1 is chosen from CR7 and N;
• Z2 is chosen from CR8 and N;
• Z3 is chosen from CR9 and N;
• R1 and R2 are independently chosen from H, CN, NH2, OH, and halo;
• R3 is chosen from H, CN, halo, hydroxy, alkyl, and alkoxy;
• R4 is chosen from H, CN, halo, alkyl, and alkoxy;
• or R4, if present, and R3, together with the intervening carbons, can form a 5-, 6-, or 7-membered cycloalkyl, heterocycloalkyl, aryl, or heteroaryl ring optionally substituted with one or more R19;
• R5, R6, R7, R8, and R9 are independently chosen from H, CN, halo, alkyl, and alkoxy;
• and
• each R19 is independently chosen from CN, halo, OH, NH2, and oxo.