Braf degraders

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof;
• wherein
• R2 and R3 are independently selected from H and C1-6-alkyl;
• or R2 and R3 together form —CH2—;
• X is selected from —CH2—, —NR4—, and —O—;
• R4 is selected from H and C1-6-alkyl;
• A is selected from:
• Re is independently selected from halogen, cyano, and C1-6-alkyl;
• t is selected from 0, 1, and 2;
• Rf is independently selected from H, C3-8-cycloalkyl, and C1-6-alkyl;
• B is absent or selected from:
• Rg is independently selected from halogen, hydroxy, and C1-6-alkyl;
• Rt is independently selected from H, C3-8-cycloalkyl, and C1-6-alkyl;
• u is independently selected from 0, 1, and 2;
• E is absent or selected from
• Ri is independently selected from halogen, hydroxy, C3-8-cycloalkyl, and C1-6-alkyl;
• v is independently selected from 0, 1, and 2;
• m and n are independently selected from 0, 1, 2, and 3;
• Ra, Rb, Rc and Rd are independently selected from H and C1-6-alkyl;
• A4 is selected from a bond and —NR101—;
• R101 is selected from H and C1-6-alkyl;
• w is selected from 0 and 1;
• A3 is selected from a bond, —O—, —NR200—, and
• R200 is selected from H and C1-6-alkyl;
• C is selected from:
• Rm is independently selected from halogen, hydroxy, C3-8-cycloalkyl, and C1-6-alkyl;
• y is independently selected from 0, 1, and 2;
• D is selected from:
• Rp is independently selected from halogen, C3-8-cycloalkyl, halo-C1-6-alkyl, C1-6-alkyl, cyano, C1-6-alkyl sulfonyl, and C3-8-cycloalkylsulfonyl;
• z is independently selected from 0, 1, and 2;
• R100 is selected from H, halogen, and C1-6-alkyl;
• R7 and R8 are independently selected from H, C1-6-alkyl, and halogen;
• A1 is selected from —NRS—and —CHR6—;
• R5 is selected from H and C1-6-alkyl;
• or R1 and R5 together with the nitrogen atom to which they are attached form a heterocycloalkyl optionally substituted by R14, R15 and R16;
• R6 is selected from H and C1-6-alkyl;
• or R1 and R6 together with the carbon atom to which they are attached form a cycloalkyl optionally substituted by R14, R15 and R16;
• R14, R15 and R16 are independently selected from C1-6-alkyl and halogen;
• and
• R1 is selected from C1-6-alkyl and C3-8-cycloalkyl.