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US 2023/0145276 A1Published application
Aerosolized formulations of an apelin peptide and uses thereof
OwnerJohn CHAN, Jayakumar RAJADAS +1inventors
InventorsJohn CHAN, Jayakumar RAJADAS, Larry STEINMAN
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Abstract
The present disclosure provides apelin formulations, and methods and devices of delivering apelin formulations to an individual. Also provided are methods of preventing and/or treating coronavirus-associated diseases in an individual comprising administering to the individual an effective amount of an apelin formulation comprising an apelin peptide.
Claims32
An aerosolized formulation of an apelin peptide comprising an effective amount of the apelin peptide that is at least partially encapsulated in a liposome comprising an amount of each of the following:
- at least one poloxamer, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and a polyethylene glycol (PEG).
Dependencies are inferred from the claim text.