Artificial immunohistochemical image systems and methods
AssigneeTempus Labs, Inc.
InventorsMadhavi Kannan, Brian Larsen, Aly Khan, Ameen Salahudeen
Life of this patent
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Abstract
The disclosure provides a method of generating an artificial immunohistochemistry (IHC) image of cells. The method includes receiving a hematoxylin and eosin (H&E) stained whole slide image (WSI) generated by a brightfield microscopy imaging modality of at least a portion of cells included in a specimen, applying, to the H&E brightfield image, at least one trained model, the trained model being trained to generate the artificial IHC image based on the H&E brightfield image, receiving the artificial IHC image from the trained model.
Claims21
1-30. (canceled)
A method of generating an artificial immunohistochemistry (IHC) stained image of cells, without IHC staining, comprising:
- receiving, by a computer system having at least one processor, a hematoxylin and eosin (H&E) stained image generated by a brightfield microscopy imaging modality of at least a portion of cells included in a specimen (brightfield H&E image) derived from a patient;
- applying by the processor, to the brightfield H&E image, at least one trained model, wherein the trained model is trained to modify pixel intensities of the brightfield H&E image so as to generate the artificial IHC image of the cells based on the brightfield image;
- and
- generating the artificial IHC image by the trained model.
A pathology slide analysis system comprising at least one processor and at least one memory, the system configured to
- receive an H&E stained image generated by a brightfield microscopy imaging modality from at least a portion of cells included in a specimen (brightfield H&E image);
- apply, via the processor, to the brightfield H&E image, at least one model trained to modify pixel intensities of the brightfield H&E image so as to generate an artificial IHC image based on the brightfield H&E image without IHC staining, the artificial IHC image being indicative of whether the cells included in the specimen are positive or negative for an IHC target molecule;
- generating the artificial IHC image by the trained model;
- and
- output the artificial IHC image to at least one of a memory or a display.
A method of generating an artificial IHC image of cells without IHC stain, comprising;
- receiving, from a computer system having at least one processor, an H&E stained image generated by a brightfield microscopy imaging modality from at least a portion of cells included in a specimen (brightfield H&E image);
- applying, by the processor, to the H&E brightfield image, at least one model trained to modify pixel intensities of the H&E brightfield image so as to generate an artificial IHC image of the cells based on the H&E brightfield image, the artificial IHC image being indicative of whether the cells included in the specimen are positive or negative for an IHC target molecule;
- generating the artificial IHC image by the trained model;
- and
- generating a report based on the artificial IHC image of the cells.
Dependencies are inferred from the claim text.