Inhibitors of fibroblast activation protein

A compound of formula (A):

• a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, wherein:
• R is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, or C6-C14 aryl, wherein the C1-C6 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, and C6-C14 aryl of R are independently optionally substituted by Rd;
• RM is hydrogen or optionally substituted C1-C6 alkyl;
• m is 0, 1, 2, 3, or 4;
• n is 0, 1, 2, 3, or 4,
• wherein m+n is 1, 2, 3, or 4;
• X is —C(═O)—, —O—, —CH(OH)—, —S—, —S(═O)—, or —S(═O)2—;
• Y is
• wherein:
• the wavy line represents the point of attachment to the rest of the molecule,
• s is 1, 2, 3, or 4,
• R11 and R12 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C4-C8 cycloalkenyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, halogen, cyano, —OR14, —NR15R16, —SR14, —NO2, —C═NH(OR14), —C(O)R14, —OC(O)R14, —C(O)OR14, —C(O)NR15R16, —NR14C(O)R15, —NR14C(O)OR15, —NR14C(O)NR15R16, —S(O)R14, —S(O)2R14, —NR14S(O)R15, —NR14S(O)2R15, —S(O)NR15R16, —S(O)2NR15R16, or —P(O)(OR15)(OR16), wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C4-C8 cycloalkenyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, and C6-C14 aryl of R11 and R12 are each independently optionally substituted by one or more of RL;
• each R13 is independently C2-C6 alkenyl, C2-C6 alkynyl, —NR15R16, —NO2, —C═NH(OR14), —C(O)R14, —OC(O)R14, —C(O)OR14, —C(O)NR15R16, —NR14C(O)R15, —NR14C(O)OR15, —NR14C(O)NR15R16, —S(O)R14, —S(O)2R14, —NR14S(O)R15, —NR14S(O)2R15, —S(O)NR15R16, —S(O)2NR15R16, or —P(O)(OR15)(OR16), wherein the C2-C6 alkenyl, and C2-C6 alkynyl of R13 are each independently optionally substituted by one or more RL;
• each R14 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R14 are independently optionally substituted by halogen, —OH, oxo, cyano, or C1-C6 alkyl optionally substituted by halogen, —OH, or oxo;
• R15 and R16, independently of each other and independently at each occurrence, are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R15 and R16 are independently optionally substituted by halogen, —OH, oxo, cyano, or C1-C6 alkyl, optionally substituted by halogen, —OH, or oxo,
• or R15 and R16 are taken together with the atom to which they are attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo, cyano, or C1-C6 alkyl optionally substituted by halogen, —OH, or oxo;
• Rd, independently at each occurrence, is halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, 3- to 12-membered heterocyclyl, —OR14, —NR15R16, cyano, or nitro;
• and
• each RL is independently halogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, C6-C14 aryl, 5- to 10-membered heteroaryl, 3- to 12-membered heterocyclyl, —C(O)R14, —OC(O)R14, —C(O)OR14, —C(O)NR15R16, —NR14C(O)R15, —NR14C(O)OR15, —NR14C(O)NR15R16, —S(O)R14, —S(O)2R14, —NR14S(O)R15, —NR14S(O)2R15, —S(O)NR15R16, —S(O)2NR15R16, —P(O)(OR15)(OR16), —NR15R16, cyano, oxo, or nitro, wherein (1) the C1-C6 alkoxy is optionally substituted by halogen, —OH, oxo, cyano, C1-C6 alkoxy, or C1-C6 alkyl optionally substituted by halogen, —OH, or oxo, (2) the C1-C6 alkyl is optionally substituted by 5- to 10-membered heteroaryl or 3- to 12-membered heterocyclyl, wherein the 3- to 12-membered heterocyclyl is further optionally substituted by C1-C6 alkyl, (3) the 5- to 10-membered heteroaryl is optionally substituted by oxo, and (4) the C3-C8 cycloalkenyl is optionally substituted by halogen, —OH, oxo, cyano, C1-C6 alkoxy, or C1-C6 alkyl.