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US 2023/0144725 A1Published application
Lrrk2 inhibitors
AssigneeH. Lundbeck A/S
InventorsThomas Jensen, Mikkel Jessing, Wanwan YU, David Rodriguez Diaz, Jacob Nielsen, Christopher Richard Jones, Thomas Andersen, Mikkel Fog Jacobsen
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Abstract
The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.
Claims19
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein:
- R1 is CH2R4 or R4;
- R2 is a C1-C3 alkyl, an isotopically labelled C1-C3 alkyl, a C3-C6cycloalkyl, or a C1-C3 haloalkyl;
- R3 is halogen, cyano, a O—C1-C3 haloalkyl, a C1-C3 haloalkyl, a C3-C6cycloalkyl, or a C1-C3 alkyl;
- R4 is a 4- to 7-membered heterocycle having 1-2 heteroatoms independently selected from oxygen and nitrogen;
- a C1-C3alkyl, a C1-C3 cyanoalkyl, a C1-C3haloalkyl, or a C3-C6cycloalkyl;
- or R4 is a bicyclic 8-membered heterocycle having 1-2 heteroatoms independently selected from oxygen and nitrogen;
- wherein each heterocycle or cycloalkyl is unsubstituted or substituted with 1, 2, or 3 groups independently selected from the group consisting of cyano, deuterium, halogen, C1-C3 alkyl, an isotopically labelled C1-C3 alkyl, a O—C1-C3 haloalkyl, a O—C1-C3 alkyl, or a C1-C3 haloalkyl.
4 more elements
Dependencies are inferred from the claim text.